An Italian rapper was be performing on stage at the Lanterna Azzura nightclub in Corinaldo before sprayed a "noxious substance" similar to pepper spray ate around 12am GMT (1am local time).
He said he did not have confirmation from survivors that the use of an irritating spray, like pepper spray, had set off the panic.
Three girls, two boys and an adult woman, who had accompanied her daughter to the disco in Corinaldo, died at the event on Saturday where an Italian rapper was entertaining the crowd, police chief Oreste Capocasa said in nearby Ancona.
"We ran to one of the emergency exits but we found it blocked, the bouncers told us to go back". More than 100 other people were injured, including a dozen who were seriously hurt.
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Some of those with minor injuries were treated and released from a hospital, he said. The barrier then appeared to give way, and a cascade of teenagers tumbled over it, falling on top of each other.
A 16-year-old boy told ANSA news agency disco patrons were dancing while waiting for the concert to start when the stampede erupted. Another eyewitness said a wall inside the club had collapsed in the melee.
The ages of the victims were not immediately given and it was not yet clear how many people were inside when the stampede erupted.
The Italian police have opened an investigation into the cause of the incident.
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