Chinese scientist claims world's first gene-edited babies

Chinese scientist claims world's first gene-edited babies

Scientists and bioethics experts reacted with shock, anger, and alarm Monday to a Chinese researcher's claim that he helped make the world's first genetically edited babies.

The researcher, He Jiankui of Shenzhen, said he altered embryos when parents were undergoing fertility treatments to change a gene so that it might provide the resulting babies with a trait few people naturally have - protection against future infection with the AIDS virus.

Reuters reports that the Southern University of Science and Technology notes in a statement that it "strictly requires scientific research to conform to national laws and regulations and to respect and comply with global academic ethics and standards".

Instead, the appeal was to offer couples affected by HIV a chance to have a child that might be protected from a similar fate.

Baylis said there are a number of potential harms from the research, both to the children involved and society at large.

"I think this just shows the time is now that you have to talk about the ethics of genome editing, because the world may not wait", said Insoo Hyun, a bioethicist at Case Western Reserve University.

It's only recently been tried in adults to treat deadly diseases, and the changes are confined to that person. A single sperm cell, he says, was placed into a single egg and an embryo was thus formed. Specifically, He deleted a region of a receptor on the surface of white blood cells known as CCR5 using the revolutionary genome-editing technique called CRISPR-Cas9. His work has resulted in one pregnancy so far.

The university issued a statement after He said in five videos posted on Monday that he used a gene-editing technology known as CRISPR-Cas9 to edit the genes of twin girls.

"Gene surgery is and should remain a technology for healing", He added. At 3-5 days old, the embryos were checked for editing.

Khashoggi murder suspect contacted Saudi national living in Yalova
Turkish police conduct a search at a villa in the village of Samanli in Yalova's Termal district, Turkey, on November 26, 2018.

Alien: Blackout will likely be announced at the Game Awards
Trademark applications do not always result in announcements of a new product. A new Alien game for console and PC was announced in January this year .

‘Good chance of death’: Musk to move to Mars
Today, the USA pays $81 million per seat in Russian Soyuz spacecraft - the only option of getting humans into space at the moment. In a recent interview for Axios on HBO , Musk said the likelihood that he will personally go to Mars is 70 percent.

"Right after sending her husband's sperm into her egg, an embryologist also sent in CRISPR/Cas9 protein and instructions to perform a gene surgery meant to protect the girls from future HIV infection", he said.

In general, those with one copy of the gene can still contract HIV, but there are chances that their rate of decline, when it comes to health could happen more slowly if they do.

They also noted evidence that the editing was incomplete and that at least one twin appears to be a patchwork of cells with various changes.

With genomics becoming more widely discussed as a scientific and social topic in recent years, He's gene-edited babies have ignited controversy on Chinese social media. It is unknown whether the procedure is safe or, if used in pregnancy, whether it can have unintended consequences for the babies later in life or for future generations.

The gene editing tools modified a gene called CCR5.

"It's nearly like not editing at all" if only certain cells go through adjustment, HIV infection can still occur, Church said.

The group's pioneer that shares the namesake of the editing technology has enrolled its first patient in a European study and recently opened enrollment in the US for patients with severe sickle cell disease in trials with partner Vertex Pharmaceuticals Inc.

Tim Caulfield, a professor of health and law at the University of Alberta, said he believes there is "an emerging worldwide consensus that this research should progress" but added that "we're not at the state right now where we want to be using this technology in the clinic".

On consent forms that the parents were asked to sign, He called his work "AIDS vaccine development", the AP reported, so it is not clear if the parents of the girls understood what he planned to do. Numerous studies have provided guidance for the conduct of heritable genome-editing clinical trials. Some research suggests that while knocking out the CCR5 would help the twins resist HIV infection, they might become more susceptible to infection by West Nile virus. Eleven embryos were used in six attempts before the twin pregnancy was achieved, Mr He said. "But I believe families need this technology". If it causes unwanted side effects or harm, "I would feel the same pain as they do and it's going to be my own responsibility".

Related:

  • GM to close factories in Michigan, Ohio, Canada

    GM to close factories in Michigan, Ohio, Canada

    Things are much worse in the United States, where the automaker has announced plans to stop production at four plants from 2019. The reduction includes 8,100 white-collar workers, some of whom will take buyouts and others who will be laid off.
    Nooses found by Mississippi Capitol day before Senate runoff

    Nooses found by Mississippi Capitol day before Senate runoff

    News reports that the nooses were found on Monday morning, along with hate signs, outside the capitol building. He says the matter is under investigation, and he did not immediately know what was on the signs.
    Border Patrol Arrests 42 Migrants While Mexico Deports Others

    Border Patrol Arrests 42 Migrants While Mexico Deports Others

    The Los Angeles Times reported at the time that agents were pelted with rocks and bottles, leaving several injured. However, they were met with pepper spray and smoke pellets, according to The Epoch Times , and quickly dispersed.
  • Mueller says Manafort violated plea agreement by lying to investigators

    Mueller says Manafort violated plea agreement by lying to investigators

    Mueller continued on to recommend that Manafort be sentenced for the crimes that he admitted to in the plea deal. Before the plea, Manafort's defenders had long insisted that he would not cooperate with Mueller.
    ESPN Analyst Crushes North Carolina’s New Coaching Hire

    ESPN Analyst Crushes North Carolina’s New Coaching Hire

    Brown will be 68-years-old by the time the next season starts, and has been out of coaching for five years. He's part of the 2018 College Football Hall of Fame class and won the 2005 national championship at Texas.
    Russian Federation  vs. Ukraine War? Ukrainian President Says Neighbor Is Preparing Ground Attack

    Russian Federation vs. Ukraine War? Ukrainian President Says Neighbor Is Preparing Ground Attack

    He warned that the media should not be diverted from the Azov Sea episode by following any Kremlin narrative about the proposed . The strait is crossed by the recently completed Kerch Bridge, connecting Crimea to Russian Federation .
  • European Union  court throws out case seeking annulment of Brexit talks

    European Union court throws out case seeking annulment of Brexit talks

    He also foreshadowed coming, fraught, negotiations by demanding access to British fishing grounds after Brexit . Britain's 300-year-old naval base in Gibraltar on Spain's southern coast, had also threatened to derail plans.
    Super Smash Bros. Ultimate Is Already Breaking Records With Pre-Orders

    Super Smash Bros. Ultimate Is Already Breaking Records With Pre-Orders

    You can collect these by unlocking challenges on the Spirit Board, and through the single-player World of Light adventure mode. They've been slowly revealing the modes, the characters, the moves, the Assist Trophies and Pokemon, and much more.
    Oprah Winfrey's mother dies age 83

    Oprah Winfrey's mother dies age 83

    Winfrey has been open about the rough relationship she had with her mother early on, though the two became closer in later years. She was the number one supporter of Pat's [Alisha's restaurant] and was the person who named our restaurant.
  • Iran's Rouhani calls Israel a 'cancerous tumor'

    Iran's Rouhani calls Israel a 'cancerous tumor'

    Earlier this year, Iran's spiritual leader, Ayatollah Ali Khamenei, also called on Muslim nations to unite against the U.S. Iran supports groups like Hezbollah and Hamas that have pledged to fight Israel's occupation of Palestine.
    NASA spacecraft lands on red planet after six-month journey

    NASA spacecraft lands on red planet after six-month journey

    Settling In InSight's first few days on the Red Planet won't be as eventful as the probe's nerve-wracking descent and landing . The stationary 360-kilogram lander will use its 6 feet robotic arm to place a mechanical mole and seismometer on the ground.
    ‘We Will Close the Border Permanently if Need Be’

    ‘We Will Close the Border Permanently if Need Be’

    He said on Twitter yesterday: "To those in the caravan, turnaround we are not letting people into the United States illegally ". The breakoff group from the migrant caravan were met and stopped by Mexican police; Jonathan Hunt reports from Los Angeles.

Comments

Latest news

Subdued migrants at Tijuana border camp mull options
He said the US Border Patrol's use of force policy allows agents to use tear gas, but added the incident would be reviewed. He said the aim of Sunday's march was to make the migrants' suffering more visible to USA and Mexican officials .

It Would Be "Impossible" To Renegotiate Brexit Withdrawal Deal Warns Italian MEP
The research was undertaken by the National Institute of Economic and Social Research (NIESR) and commissioned by the People's Vote campaign.

US Lawmakers Split With Trump on Khashoggi Killing
The Trump administration has imposed sanctions on 17 individuals that Saudi Arabia said were connected in Khashoggi's death. Trump has resisted calls to punish Saudi Arabia, pointing to the kingdom's purchase of weapons from USA arms manufacturers.

Donald Trump demands Mexico moves migrants from the United States border
It was not immediately clear whether those throwing objects at U.S. agents were part of the caravan, MSNBC reported . There were some sections that had the dilapidated border wall that was made out of scrap metal the military gave us.

Carlos Ghosn removed as Mitsubishi chairman in boost to Nissan
Its current chief executive Osamu Masuko will take on the additional role of acting chairman pending a shareholder meeting. Nissan removed Carlos Ghosn at a high stakes board meeting but Renault has refrained from firing him as chairman and CEO.

Cavs have reached out to Sixers about Markelle Fultz
The possibility of Fultz moving on is understandable considering how confusing things have been with the Sixers. Fultz, 20, is averaging 8 points, 3 assists and 3 rebounds a game for Philadelphia so far this season.

Melania Trump unveils White House Christmas decorations
The tree hails from a farm in Avery County, North Carolina, and was hand-selected by the National Christmas Tree Association. Louis, and Chicago and are meant to highlight "diversity and ingenuity of American architecture and design".

General Motors To Lay Off Nearly 15,000 Workers, Close Plants
The US automaker has other operations in Canada, including a plant in Ingersoll, Ontario, where it assembles Chevrolet Equinox. GM's Oshawa plant assembles the Chevrolet Impala and Cadillac XTS and finishes Chevrolet Silverado and GMC Sierra trucks.

Target's Cyber Monday Deals Do Not Disappoint
Target was offering 30 per cent off on select toys, while Kohl's discounted Lego sets between 30 per cent and 40 per cent. The long shopping weekend isn't over just yet, as Amazon's Cyber Monday 2018 deals have gone live in Canada.

Why Prince Harry and Meghan Markle Are Moving Out of Kensington Palace
The couple were originally scheduled to move into a Kensington Palace apartment next to William and Kate . It had been claimed tensions between the two brothers had caused the change of plans.

General Motors to cut 14000 jobs as seven factories close worldwide
The union representing the autoworkers, Unifor, said at the time the investment dispelled fears the factory would close in 2019. In 2009, GM shut down truck assembly at the plant, citing high gas prices and a deep recession caused by the financial crisis.

Climate change could cost United States 'hundreds of billions' a year, report warns
CNN also gave the report front page treatment on its website Friday, as did the LA Times and the Chicago Tribune . The president announced past year his intention to withdraw the US from the landmark Paris climate agreement.

American on deadly trip to Indian island: ‘God sheltered me’
He knew how risky it would be, and told people about his trip plan as long ago as 2016, a friend told BuzzFeed News and CNN. The Anthropological Survey of India has had previous rudimentary contact with the tribe - with one of its officials, C.

Italy's rugby team don rainbow laces for Welsh legend
New Zealand said in a tweet on Friday its players would wear the rainbow laces in a tribute to Thomas in Saturday's test match against Italy .

Red Dead Online Goes Live This Week
According to THR , the beta will begin tomorrow, November 27th and then there will be full public access on Friday, November 30th. Players can hunt, fish and create a camp, and of course visit all the locations on the map that were in Red Dead Redemption 2 .

Other news