Scientists behind cancer immunotherapies win Nobel Prize in medicine

A screen displays portraits of James Allison and Tasuku Honju winners of the 2018 Nobel Prize in Physiology or Medicine during a press conference at the Karolinska Institute in Stockholm on Oct 1 2018

Working out of the University of California, Berkeley, in the 1990s, Allison (who's now at Houston's MD Anderson Cancer Center and a seminal force within an exciting collaboration called the Parker Institute for Cancer Immunotherapy), figured out how one such "off" switch, or "immune checkpoint", known as CTLA-4, could be flipped to preempt an attack by immune defenders called T cells.

Tasuku Honjo of Japan "discovered a protein on immune cells and revealed that it also operates as a brake, but with a different mechanism of action". By releasing this brake, the body's own immune system can be stimulated to attack tumors.

One famous recipient of the new treatment is former United States president Jimmy Carter.

That theory, tested and honed in the lab, led to the development of ipilimumab, used on patients with melanoma, an aggressive skin cancer that had spread and invaded other parts of the patients' bodies.

The discovery made by these scientists has revolutionized treatment and improved the prognosis of multiple tumors over the past five years by harnessing the immune system's ability to attack cancer cells.

Man at centre of Nobel Literature scandal convicted of rape: THE man at the centre of a sex-abuse and financial crimes scandal that is tarnishing the academy that awards the Nobel Prize in Literature was convicted of rape and sentenced to two years in prison on Monday. "Doing basic science can have major results in human health care", he says. Allison and Honjo will share a $1 million prize.

Amazon introduces Fire TV Stick 4K with Alexa Voice Remote in India
It's the newest update to its best-selling Fire TV stick and, according to the company, 80 percent more powerful. To work with the latter, Amazon has added a volume rocker, a mute button and a power button.

Donald Trump mocks Brett Kavanaugh accuser he had called credible witness
The White House rebutted these claims with statements from two former Yale classmates of Judge Kavanaugh. But Mr Trump also questioned why investigators needed to examine Mr Kavanaugh's high school record.

Oil Falls but Stays Near Four-year Highs
Global benchmark Brent crude oil futures LCOc1 were at $85.28 per barrel, up 30 cents, or 0.4 percent, from their last close. WTI for November delivery traded at $73.55 a barrel on the New York Mercantile Exchange, up 30 cents.

Independently, Honjo had discovered PD-1, another protein in T-cells. While Allison is an American professor and chair of immunology and executive director of immunotherapy platform at the MD Anderson Cancer Center in Texas, Honjo is the deputy director-general and distinguished professor of Kyoto University Institute for Advanced Study.

"We know that some patients have a very low chance of responding. those with little evidence that these pathways are actively restricting the immune system, or those with cancers that are less heavily mutated", he said. The award was announced in a statement from the Nobel Assembly at Karolinska Institutet on Monday. "Clearly, immunotherapy now has taken its place along with surgery, chemotherapy and radiation as a reliable and objective way to treat cancer". When the treatments work, the cancer goes into remission. Surgeon William Coley had developed an approach to treating cancer that involved injecting patients with a mixture of heat-killed bacteria in the hopes of stimulating the body's "resisting powers".

Houston, Oct 2 James Allison, the victor of the 2018 Nobel Medicine Prize, has said he never dreamed that his research would take the direction it has. "But now I am able to play golf again".

No Nobel Literature Prize is being given this year because the Swedish Academy, the body that choses the literature victor, has been in turmoil after sex abuse and financial scandal allegations.

Allison said more scientific work is needed to learn to combine immunotherapy with conventional treatment to stifle tumor growth. Clinical trials are underway in many other cancer types. In a key mouse experiment around Christmas 1994, Allison found that when mice with cancer were treated with CTLA-4-blocking antibodies, they were cured.

Related:

  • Legendary French singer Charles Aznavour dies aged 94

    Legendary French singer Charles Aznavour dies aged 94

    In 2015, he released his 51st album, Encores, and received a star on Hollywood's Walk Of Fame just previous year . Aznavour won fans around the world with his versatile tenor, lush lyrics, and kinetic stage presence.
    Duchess Kate makes first solo outing after birth of third child

    Duchess Kate makes first solo outing after birth of third child

    She spent the day with a group of children taking part in a number of activities, including making crowns out of paper and leaves. As for the sweater and raincoat, it's possible they're new but the whole look resembles this outfit from a 2017 visit to a farm.
    New York Tax Department Reviewing Allegations of Trump Family Transactions

    New York Tax Department Reviewing Allegations of Trump Family Transactions

    Fred Trump gave millions to his kids in a way that was structured to sidestep taxes on gifts and inheritances. By the time he was 3 years old, Trump was earning $US200,000 a year in today's dollars.
  • Players Are in Love With Spider-Man PS4's Photo Mode

    Players Are in Love With Spider-Man PS4's Photo Mode

    Schultz replied back , saying that since they'd been together five years "I think she'll still be around in September lol". Since Tyler asked Insomniac to put the message into the game, he and his partner have since split in a dramatic fashion.
    Boris Johnson addresses fringe event at Conservative Party conference

    Boris Johnson addresses fringe event at Conservative Party conference

    Mr Johnson used his appearance on Tuesday to make the case for greater economic freedom after Brexit and lower taxes. It is risky and unstable - politically and economically, ' he said.
    ‘Very scary time’ for young American men, says Trump

    ‘Very scary time’ for young American men, says Trump

    While Kavanaugh was not "perfect with respect to alcohol", Trump said he knew opposition Democrat senators who are not "angels". Mr Trump said it was a "very scary situation " to be "guilty until proven innocent".
  • Massive LNG project in northern BC reportedly given the go-ahead

    TransCanada will seek financing and joint venture partners for the pipeline , which is slated to begin service in 2023. A total of $40 billion CAD will be invested in the project over the next several years.
    Amitabh Bachchan: Krishna Raj Kapoor kept vast family of celebrated individuals together

    Amitabh Bachchan: Krishna Raj Kapoor kept vast family of celebrated individuals together

    Although she used to be in and out of the hospital owing to age-related issues since the past few years, we never saw this coming. After Raj Kapoor's death in 1988, she held the entire family together and was exclusively responsible for her five kids.
    Samsung set to release silver-colored Galaxy Note 9

    Samsung set to release silver-colored Galaxy Note 9

    At PC Magazine , Sascha Segan has compared LTE speeds of the iPhone X to XS, and the latter is substantially faster. The feature also helps boost the device's performance when the signal conditions are weak, the report notes.
  • Malaysia again questions former PM and wife in 1MDB probe

    Malaysia again questions former PM and wife in 1MDB probe

    Anti-graft investigators spent almost 13 hours recording Rosmah's statement last week as part of their inquiry into 1MDB. Rosmah Mansor smiled at reporters but didn't speak as she was escorted into the agency's building.
    Trump says Brett Kavanaugh had a 'bit of a difficulty' with alcohol

    Trump says Brett Kavanaugh had a 'bit of a difficulty' with alcohol

    Senate Majority Leader Mitch McConnell said a vote would happen on Kavanaugh's nomination by the end of the week. FILE - In this September 4, 2018 photo, Supreme Court nominee Brett Kavanaugh, listens to Sen.
    Molitor out as Twins manager

    Molitor out as Twins manager

    Paul Molitor won't return as manager of the Minnesota Twins next season, the team announced on Tuesday. The Minnesota Twins have fired Paul Molitor .

Comments

Latest news

Manchester United BOOED OFF by fans after dour draw with Valencia
Mourinho was furious that the journey from the Lowry took well over an hour, with the team setting off at 6pm and not arriving until 7.15pm.

If The FBI Finds Nothing, Most Americans Want Kavanaugh Confirmed
Before departing the White House, Trump tweeted, "THE ONLY REASON TO VOTE FOR A DEMOCRAT IS IF YOU'RE TIRED OF WINNING!" Facing a three-way race between Democrat Mike Espy and far-right Republican state Sen.

Here is Chiefs quarterback Patrick Mahomes’ left-handed throw against Denver
Each scored a touchdown and Freeman eluded seven defenders and dragged a linebacker into the end zone on his 14-yard score. It was the first time since 2004 that the team dropped a home game in which it led by double digits in the fourth quarter.

Volcano now erupts on same Indonesian island reeling from natural disaster and tsunami
He said the government was coordinating emergency efforts, and United Nations and relief agencies were on the ground or en route. Indonesian men survey the damage following earthquakes and a tsunami. "Logistics, fuel are still limited", Nugroho said.

Russian Federation completed S-300 delivery to Syria: Defence minister
Russian Foreign Minister Sergei Lavrov announced the deliveries had started during a United Nations press conference. Capability: Russian 48N6E are the standard missiles fired from S-300PMU launchers.

Jon Lester has very candid response to Cubs wild-card game loss
Lester is no stranger to October baseball, as he's set to make his 22nd postseason start and his second in the Wild Card game. They squandered a dominant start by Jon Lester , got shut down by Kyle Freeland and wasted several big scoring opportunities.

Antonio Valencia sorry for liking Jose Mourinho sacking post
United play Newcastle on Saturday at Old Trafford in the final round of Premier League fixtures before the worldwide break. Fans, experts and critics are calling for Jose Mourinho's head after a run of bad results.

4 arrested for series of Los Angeles celebrity burglaries
In 2017, singer Alanis Morissette had $2 million (£1.54m) in jewellery and valuables stolen from her mansion in Brentwood, LA. Charges were not immediately filed against the other three suspects who remain in jail, according to the AP.

A Very Tarnished Court
And the rally in Southaven, Miss., on Tuesday night, Trump went further. "I could tell you things about everyone one of them". As Republicans fight headwinds ahead of the November 6 midterm election, Trump sought to rally his supporters behind GOP Sen.

Iwobi Shines off the bench for Arsenal in 7th Straight Win
Emery called on the pre-season signing from Bayer Leverkusen to seize his chance, saying: "I'm very happy with Leno". However, the new management structure at Arsenal means Emery has little say when it comes to contract negotiations.

Brewers vs Rockies: NLDS Preview and Prediction
Chicago wouldn't go away quietly, with Anthony Rizzo knotting the game back up in the fifth with a 429 foot shot to right field. The victor will not only win the NL Central , but will secure the best record in the National League.

After days of restraint, Trump mocks Kavanaugh accuser
Deborah Ramirez, who said Mr Kavanaugh exposed himself to her at a party, is also understood to have now been interviewed. A lawyer for Mr Judge, who has denied any wrongdoing, declined to say when the interview finished or what he was asked.

Misfiring Real Madrid stumble again, Juventus win without Cristiano Ronaldo
At the time the report was taken, the victim did not provide detectives with the location of the incident or suspect description. The lawsuit said Mayorga also went to a hospital, where a sexual assault medical examination was conducted.

Burials begin in Indonesia as survivors' desperation grows
Quake victims in Palu set up tents in front of city hall in an attempt to get aid quicker but are also hoping for foreign support. The European Union and about 10 other countries have offered assistance, including the United States and China.

Fan Bingbing: Top Chinese actress fined for tax evasion
I'm so ashamed of what I've done. "I know I've let down the country, betrayed society's trust in me, and let down my fans . Fan appeared in the X-Men and Iron Man film franchises and has more than 62 million followers online in China.

Other news