From there, the tall and powerful Anderson kicked on whilst Federer stalled.
Back to deuce. From there, it all began to change.
In the fourth set, Federer and Anderson alternated winning the first six games until Anderson broke Federer's serve to take a 4-3 lead and then Anderson went up 5-3 thanks to strong serving before he clinched the set.
The comeback was just beginning. "I think I had my chances, so it's disappointing".
Update: Federer not only dropped his first set, but his second as well. In his first four matches the Swiss had been utterly dominant on serve, winning 92 % of points on first serve, his best ever serving stats in his 20 years at Wimbledon.
"So no, I didn't see it coming".
From there, Anderson came all the way back, shocking Federer with a 13-11 triumph in the fifth and final set, capping off the four-plus hour match with a bullet serve up the middle that Federer returned long. But there was more.
Federer was attempting to reach his 13th semi-final at Wimbledon and move closer to title number nine, both of which would have broken his own records.
Federer is a flawless 12-0 in Sets thus far and a ideal 4-0 in Matches at Wimbledon 2018.
"I just kept saying "today is going to be your day".
"If you go out there with doubts or unsure what's going to happen, like I maybe did a little bit in that first set, it's not going to go your way". Depends against who you play you have less or more chances to win.
England V. Croatia, Winner Will Play France Old Christchurch Road to Horseshoe Common, Westover Road and Gervis Place will be closed and bus routes will also be affected. Nick Colgan, originally from South Yardley in Birmingham, has lived in the country for the past 15 years.
But Anderson is not letting his thoughts run away, drawing on his experience of reaching the final of last year's US Open. However, when Anderson and Isner face off, there will be plenty of aces and quick points. Where once he would have buckled on the big stage against someone like Federer he now relishes the task. "You're never really safe".
Federer was completely out of sorts by now and his uncharacteristic struggles on his forehand didn't improve in the fourth set.
Anderson then served it out, ending things with a 205kph service victor, and raised both arms overhead.
With the scores deadlocked at 11-11 in the final set, and no obvious break in serve forthcoming, Anderson profited as Federer started to show signs of strain. Even when he managed to do that in the second game of the second set, Federer recovered to break back and take it to a tiebreak, which the No. 1 seed won.
It was an extraordinary turnaround after Federer won the first set in 26 scintillating minutes against a player he had beaten four times out of four without dropping a set.
Anderson will now move into his first semi-finals at the tournament; taking on the victor of John Isner and Milos Raonic for a place in a final against what may be Rafa Nadal or Novak Djokovic.
That earned a code violation from chair umpire Carlos Ramos.
Later in the match, Djokovic was clearly frustrated and complained of "double standards" when Nishikori was not punished for a racket throw. He's always like a big war for me.
Later, Ramos warned Djokovic for a time violation, but that didn't seem to faze the Serb. But I wouldn't necessarily say I've been playing like incredible. "I really do. I think with the performances I've had, I deserve to be in the semi-finals", Djokovic, whose last major title came at the 2016 French Open, said.
The worrying thought about what we will do with ourselves once it is over can wait, because two well-matched semi-finals await. I could be with my parents, eating and drinking and watching the game on TV.
Nearly 11 years ago, Croatia beat England in a Euro 2008 qualifier, one that saw England miss out on the continental tournament. He hopes England will be more suited to their style of play, but added that recovering from two extended games will be hard .
The biggest thing for me is just continuing to win - and hopefully a few more wins over the next week'. It's down to what we do behind the scenes, what we work on in training, all the hard work to get here.
Upon exiting the store, she climbed in a black Nissan - the vehicle was open and the key's were in the ignition - and drove home. They even tried to explain that the model she was trying to return wasn't on file but she apparently did not want to hear it.
CPI inflation is expected to edge up further to about 2.5 per cent before settling back to 2 per cent by the second half of 2019. It was the bank's fourth increase over the last 12 months and the first time the rate has been this high since December 2008.
The team's next job is to rest up and watch England and Croatia to see who it will be facing off against. You want to test yourself as much as you can playing against the best teams and the best players.
Kate's sister, Pippa , also wore floral stud earrings for the occasion, opting for a modern gold style unlike Kate's pearls. Meade is also a cousin of Prince William's stepmother, Camilla , Duchess of Cornwall, though several times removed.
At 20, Kylie Jenner is making history as the youngest person on Forbes magazine's list of America's Richest Self-Made Women. For comparison, Forbes estimates that Jenner's older sister Kim Kardashian West is worth roughly $ 350 million .
On June 24, Israel's military said it launched a Patriot missile at an incoming drone from Syria , which turned away unscathed. Israel worries that Assad could let his Iranian and Hezbollah allies gain a foothold near Israeli lines.
World number one Nadal faces a tricky test against power-hitter del Potro in his first Wimbledon quarter-final since 2011. The other quarter-final features American John Isner and Canadian former runner-up Milos Raonic .
Pacific Northwest, and are likely to get sent elsewhere as exporters scramble to avoid paying the tariff, a U.S. trader said. Asian markets appear to have taken in stride the USA move to raise tariffs on billions of dollars of Chinese products.
MI auto racing highlights - from Daytona to Kalamazoo
Daytona 500 victor Austin Dillon didn't seem to be much of a factor, but he made it to the end of the night and finished ninth. Jones was involved in one of the many wrecks, but his No. 20 Toyota was still in good enough shape to get by Martin Truex Jr .
Wimbledon 2018: Novak Djokovic beats Kei Nishikori to make semis
The 12-time major victor prevailed despite picking up two code violations and accusing umpire Carlos Ramos of "double standards". Djokovic, three times a champion at SW19, maintained the dominance he has shown throughout the tournament on his first serve.
Markets hit as Trump threatens new tariffs on China
The US administration late on Tuesday released a huge list of new tariffs on $US200 billion worth of goods from China . Global markets are rattled this morning after America escalated the deepening trade war between the two countries.
Woman shot and killed by stray bullet in Mexico
The State Department is advising tourists to reconsider travel to Mexico State, where Mexico City is (shown in orange, center). As a mother, we always say things, but she inspired me to be better. "I'd give my life if she could just come back".
Roger Federer loses epic stunner at Wimbledon
Anderson then served it out, ending things with a 128 miles per hour service victor , and raised both arms overhead. The tennis player and cricketer know each other personally and share great mutual respect.