Alzheimer's disease reversed in mice

Source ANDRZEJ WOJCICKI Getty Images

Researchers found that gradually reducing an enzyme called BACE1 in the brain can undo damage caused by the illness. "We are grateful to the patients and caregivers who participated in this study, and despite this outcome, Merck remains committed to developing novel therapies for the treatment of Alzheimer's and other neurodegenerative diseases".

The study published in the Journal of Alzheimer's Disease focused on a type of brain tissue called white matter, which is composed of millions of bundles of nerve fibres used by neurons to communicate across the brain.

Other teams at the institute are also designing tests for the early detection of dementia risk and looking for ways to slow or prevent the spread of toxic proteins such as beta-amyloid and tau, which destroy certain nerve cells in the brain. "Future studies should develop strategies to minimize synaptic deficiency resulting from significant inhibition of BACE1 to achieve maximum and optimal benefits for patients with Alzheimer's", says Yan.

Already aware of the Merck failure, Yan told Daily Mail Online last night that he still believes BACE1 is the answer to preventing and treating Alzheimer's.

Verubecestat is a small molecule inhibitor of the beta-site amyloid precursor protein cleaving enzyme (BACE1).

There was one ringing endorsement this morning for BACE1 as a prospect to tackle Alzheimer's: a team at Cleveland Clinic published a paper showing they had successfully reversed Alzheimer's in a middle-aged lab mouse. In many trials, mice completely lacking BACE1 suffer severe neurodevelopmental defects.

Larry Fitzgerald to return to Cardinals for 2018 season
Before then, we'll get at least one more season to marvel at his greatness on the field. He finished 2017 third on both career lists with 15,545 yards and 1,234 receptions.

Are Analysts Bearish Capita plc (LON:CPI) After Last Week?
Greencore Group plc produces and sells various food products primarily in the United Kingdom and the United States. Greencore Group has a twelve month low of GBX 180.40 ($2.49) and a twelve month high of GBX 265.30 ($3.67).

Trump budget provides $13 billion to combat opioid crisis
Lawmakers from the Great Lakes states fought off a Trump proposal to eliminate the Great Lakes cleanup program previous year . Still, the proposed cuts drew a rebuke from the top Democrat on the House of Representatives Budget Committee, John Yarmuth.

Lead scientist Dr Riqiang Yan, from the Cleveland Clinic, Ohio, said: "To our knowledge, this is the first observation of such a dramatic reversal of amyloid deposition in any study of Alzheimer's disease mouse models".

Drugs that inhibit BACE1 are therefore being developed as potential Alzheimer's disease treatments. These mice developed in a normal, healthy manner.

Sustained and increasing BACE1 inhibition can reverse amyloid deposition in a mouse model of Alzheimer's disease, according to a study published online February 14 in the Journal of Experimental Medicine. By the end of the study, the mice offspring showed absolutely no plaques at all in their brain.

On Tuesday, Merck announced in a statement that it has pulled the plug on a trial with patients given either a placebo, or 12mg or 40mg of verubecestat, once a day.

Despite some compelling recent scientific breakthroughs in Alzheimer's research over the past year, several high-profile clinical trial failures have resulted in some big companies pulling back their investments in the area.

Biogen and Eisai are also in advanced clinical trials testing a similar but subtly different BACE inhibitor - E2609 - in early-stage patients. It involves more than 600 older adults at high risk to develop Alzheimer's disease.

Related:

  • Alvaro Morata makes vow to Chelsea FC fans ahead of Barcelona clash

    Alvaro Morata makes vow to Chelsea FC fans ahead of Barcelona clash

    Elsewhere, Conte was able to provide some positive news on Alvaro Morata's condition after his recent back problems . Tiemoue Bakayoko, David Luiz and Ross Barkley are unavailable to Conte as they are all out through injury.
    Dutch FM resigns triggering vote of no-confidence

    Dutch FM resigns triggering vote of no-confidence

    The Russian embassy angrily waded into the scandal on February 13, accusing the Dutch of spreading "fake news". He then told what he had heard from Putin when he met with him 10 years ago.
    Uber Technologies loss expanded in 2017

    Uber Technologies loss expanded in 2017

    Meanwhile the amount Uber spent on customer support, sales and marketing reportedly decreased at the end of 2017. Adjusted net revenue came up to $2.22 billion, a 61 percent increase from the same period the year before.
  • Lacasse helps Canadian women's hockey team edge U.S.  in Pyeongchang

    Lacasse helps Canadian women's hockey team edge U.S. in Pyeongchang

    The puck was placed perfectly by the Canadian, but Rooney was slow to react on the play that went up and over her shoulder. Finland and OAR, teams that were expected to showcase their recent growth in PyeongChang, unfortunately, came up short.
    Pakistan bans Hafiz Saeed's charities; seizes his offices, assets

    Pakistan bans Hafiz Saeed's charities; seizes his offices, assets

    FATF maintains a grey and blacklist that identifies countries supporting money laundering and terror financing. Pakistan was on the FATF watchlist from 2012 to 2015.

    Amazon.com (AMZN) Downgraded to "Hold" at Vetr

    It increased, as 52 investors sold AAPL shares while 1034 reduced holdings. 125 funds opened positions while 492 raised stakes. Tocqueville Asset Mgmt Limited Partnership has invested 1.38% of its portfolio in Microsoft Corporation (NASDAQ:MSFT).
  • Oxfam scandal: Disgraced former Haiti director slams 'exaggerations and lies'

    Oxfam scandal: Disgraced former Haiti director slams 'exaggerations and lies'

    But she said her name remained on the charity's website because she wanted to show gratitude and support for what they try to do. International Development Minister Alasdair Allan has written to non-governmental organisations (NGOs) working overseas .

    Digital Realty Trust, Inc. (DLR): What's the Story?

    California-based Bancorporation Of The West has invested 0.97% in Intel Corporation (NASDAQ:INTC). (NYSE:V) for 913,696 shares. Deutsche Bank maintained Advance Auto Parts, Inc. (NYSE:AAP) earned "Neutral" rating by Citigroup on Wednesday, August 17.
    Litecoin (LTC) soars 25.06% on February 14-15

    Litecoin (LTC) soars 25.06% on February 14-15

    There is a catch though which has raised concerns of a scam and drawn criticism from Litecoin founder Charlie Lee. The fork is scheduled to take place on Sunday and will award Litecoin holders free Litecoin Cash .
  • This Could be the Android One Nokia 7 Plus

    This Could be the Android One Nokia 7 Plus

    With Android One , the Nokia 7 Plus will presumably see a launch with Android Oreo on board, as well as faster updates . These renders of the Nokia 7+ Android One Edition leaked by Blass give us our clearest look yet at the smartphone.
    Harden Leads Rockets to 10th Straight Victory

    Harden Leads Rockets to 10th Straight Victory

    The Charlotte Hornets also won 104-102, with 22 points from Dwight Howard helping them to victory over the Orlando Magic. Phoenix's Elfrid Payton chipped in his ninth career triple-double, finishing with 13 points, 11 rebounds and 12 assists.
    LA's Adam Rippon Hits Olympic Ice

    LA's Adam Rippon Hits Olympic Ice

    Either way, the 37-year-old Rippon says it's not the only account that's been misguided since the start of Olympic season. So, going forward, I'm taking a page out of Rippon and Davenport's bedazzled book.

Comments

Latest news

Israel and Iran are on the brink of war
Representatives of the United Kingdom and Sweden, however, have said that a draft resolution for the ceasefire is moving forward, Falk reports.

Need a job? Home Depot and Lowe's are hiring 130000 seasonal employees!
The sale was disclosed in a filing with the SEC, which can be accessed through the SEC website . (NYSE:ROK) shares. Finally, Cutter & CO Brokerage Inc. boosted its holdings in shares of Home Depot by 0.3% during the 2nd quarter.

Baltimore police guilty of robbing citizens
Prosecutors accused the officers of playing " both cops and robbers ". But some voices are calling for more than departmental reforms.

Pakistan strongly rejects allegations of Indian media about Sunjwan Camp attack
Security forces were sweeping through the camp slowly, since soldiers and their families live there, Vaid said. Another suicide attack at Karan Nagar CRPF Camp in Srinagar was repulsed on Monday morning.

Facebook's controversial Messenger Kids app is coming to Android today
To interact with other children, both the parents must have Messenger Kids authenticated and installed on their kids' devices. Today, many young children use mom or dad's hand-me-down Android smartphone as their gaming device, or an Android tablet.

Of Delaware Trims Holdings in Applied Materials, Inc. (AMAT)
LeJeune Puetz Investment Counsel LLC bought a new position in shares of Applied Materials in the third quarter valued at $105,000. It has outperformed by 104.70% the S&P500. $6.44 million worth of stock was sold by Salehpour Ali on Friday, December 29.

CNN Terror Expert Breaks Down In Tears Over Florida Shooting
After explaining how he has spoken to unwilling ISIS fighters, Mudd's voice starts to break as he implores, 'I have 10 nieces and nephews.

Fidelity MSCI Financials ETF (FNCL) Rises 1.995% for Feb 12
On the other side, a stock may be considered to be in a downtrend if trading below the moving average and sloping downward. The RSI, or Relative Strength Index, is a widely used technical momentum indicator that compares price movement over time.

Um, PF Chang Olympics? TV station apologizes for graphics flub
A local TV station in Chicago has apologized after displaying a graphic that mixed up Pyeongchang, South Korea , with P.F. The Chicago station's Pyeongchang card comes after an OH high school wrote an apology over students who yelled "P.F.

EFF won't participate in election of new president
We can be cleansed by the election process. "We can not afford to have parliament in a state of limbo", said Mthembu. But at the moment there is uncertainty whether Zuma will resign or not.

Sells 8248 Shares of Walt Disney Co (DIS)
The stock of The Walt Disney Company (NYSE:DIS) has " Buy " rating given on Wednesday, May 11 by Topeka Capital Markets. Over the past three months, The Walt Disney Company insiders have been net buyers, dumping a net of -80,717 shares.

Revenue Estimates Analysis The New York Times Company
The stock, as of last close, traded 5.07% away to its 52 week low and was at a distance of -18.56% from its 52 week high. This presents short term, intermediate and long term technical levels of GlaxoSmithKline plc ( GSK ) stock.

Liverpool ahead of Chelsea and Arsenal in race for England star
"I only heard about the story this morning and that Jack had quashed the rumours", The Sentinel quotes the manager as saying. And one impressive tournament on the grandest stage of all could light up Butland's career moving forward.

Five-storeyed under-construction building collapses in Bengaluru, 3 labourers killed
The Hindu reported that the Bellandur Police reported to the call and is now aiding and supervising rescue operations. The under construction building which fall apart is located in Haralur, on the Central Jail Road in Kasavanahalli.

Wells Fargo & Co (WFC) Lifted to "Hold" at Vetr
Company has conspicuous measure of stock oscillations; average true range may be heating up this temperature with value of 0.23. Biltmore Family Office LLC acquired a new stake in shares of Wells Fargo & Co during the fourth quarter worth about $900,000.

Other news